2′-Iodo-2,2′′,3,3′′,4,4′′,5,5′′,6,6′′-deca­methyl-1,1′:3′,1′′-terphenyl chloro­form monosolvate

The title compound, C28H33I·CHCl3, forms dimers through C—I⋯π inter­actions. The crystal structure is consolidated by the presence of C—H⋯π inter­actions between the chloro­form solvent and the main mol­ecule

Клинические вопросы – диагноз метастазах опухолей позвоночника

Catedra Ortopedie şi Traumatologie USMF „N. Testemiţanu”, Republica Moldova Catedra Hematologie, Oncologie USMF „N. Testemiţanu”, Republica Moldova Spitalul Clinic De Ortopedie si Traumatologie, Republica MoldovaSummary: Decision on surgical option of pathological vertebral fractures depends on the character of outbreak metastatic tumor histology, its spread, severity of clinical signs of disease, somatic conditions of the patient and the technical possibilities on making radical spine surgery. Key - words: metastatic spinal tumors, neo-bone formation, tumors of locomotor apparatus Резюме: Решение о хирургической манипуляции патологических переломов позвоночника зависит от характера вспышки гистологии метастатической опухоли, ее распространения, тяжести клинических признаков заболевания, соматического состояния пациента и технических возможностей создания радикальной хирургии позвоночника. Ключевые слова: метастатические опухоли спинного мозга, формирование нео-образований, опухоли двигательного оппорного аппарат

(2,4,6-Trimethyl­phen­yl)boronic acid–triphenyl­phosphine oxide (1/1)

In the crystal structure of the title compound, C9H13BO2·C18H15OP, there are O—H⋯O hydrogen bonds between the O atom of triphenyl­phosphine oxide and one hy­droxy group of the boronic acid. Boronic acid mol­ecules form inversion-related hydrogen-bonded dimers in an R 2 2(8) motif. The structure is consolidated by inter­molecular C—H⋯O bonds and C—H⋯π inter­actions

Surgical treatment of patients with spinal neoplastic diseases

Catedra Ortopedie şi Traumatologie USMF „N. Testemiţanu”, Republica Moldova Catedra Hematologie, Oncologie USMF „N. Testemiţanu”, Republica Moldova Spitalul Clinic de Ortopedie si Traumatologie, Republica MoldovaSummary: Tumors of the spine is 4-7% of the musculoskeletal system tumors. This pathology bone oncology unlike somatic effect on children and young people under the age of 40 years and 50 years found in about 2.5-3% of the total number of cases of bone tumors. The diagnosis of vertebral tumors is difficult because of the emergence of late clinical manifestations. Surgical treatments for spinal tumor disease began to evolve relatively recently, along with modern techniques and methods of 3D CT imaging system development, anesthesiology and resuscitation, modern practical implementation of modern methods sitez, bioinert implants. Резюме: Опухоли позвоночника составляет 4-7% от опорно-двигательного аппарата новообразований. Эта патология костно онкология в отличие от соматической влияет на детей и молодых людей в возрасте до 40 лет и 50 лет обнаруживается примерно 2,5-3% от общего числа случаев опухолей костей. Диагноз позвоночных опухолей представляет трудности из-за появления поздних клинических проявлений. Хирургические методы лечения опухолевой болезни позвоночника стали развиваться сравнительно недавно наряду с современными техниками и методами визуализации системы КТ развитие 3D , анестезиологии и реаниматологии, современной практической реализации современных методов ситэз, биокосных имплантатов. Ключевые слова: опухоли позвоночника, опорно-двигательного аппарата, хирургическое лечение

Activities across Africa to improve antimicrobial utilisation and reduce AMR

There are concerns with current prescribing and dispensing of antimicrobials in Africa. Point prevalence studies in hospitals shown variable rates with high rates HIV in some. Variable ASPs, extended prophylaxis and high rates self purchasing in some

Interventions to prevent neonatal healthcare-associated infections in low-resource settings: a systematic review

Background: Clinically suspected and laboratory-confirmed bloodstream infections are frequent causes of morbidity and mortality during neonatal care. The most effective infection prevention and control (IPC) interventions for neonates in low-and-middle-income countries (LMIC) are unknown. Aim: To identify effective interventions in the prevention of hospital-acquired bloodstream infections in LMIC neonatal units. Methods: Medline, PUBMED, The Cochrane Database of Systematic Reviews, EMBASE, and PsychInfo (January 2003 – October 2020) were searched to identify studies reporting single or bundled interventions for prevention of bloodstream infections in LMIC neonatal units. Results: Our initial search identified 5206 articles; following application of filters, 27 publications met the inclusion and ICROMS assessment criteria and were summarised in the final analysis. No studies were carried out in low-income countries, only one in sub-Saharan Africa and just two in multiple countries. Of the 18 single intervention studies, most targeted skin (n=4) and gastrointestinal mucosal integrity (n=5). Whereas emollient therapy and lactoferrin achieved significant reductions in proven neonatal infection, glutamine and mixed probiotics showed no benefit. Chlorhexidine gluconate for cord care and kangaroo mother care reduced infection in individual single-centre studies. Of the nine studies evaluating bundles, most focused on prevention of device-associated infections and achieved significant reductions in catheter- and ventilator-associated infections. Conclusion: There is a limited evidence-base for the effectiveness of IPC interventions in LMIC neonatal units; bundled interventions targeting device-associated infections were most effective. More multi-site studies with robust study designs are needed to inform IPC intervention strategies in low-resource neonatal units

Assessment of genetically modified maize\ua04114 for food and feed uses, under Regulation (EC) No\ua01829/2003 (application EFSA-GMO-NL-2014-123)

Maize\ua04114 was developed through Agrobacterium\ua0tumefaciens-mediated transformation to provide protection against certain lepidopteran and coleopteran pests by expression of the Cry1F, Cry34Ab1 and Cry35Ab1 proteins derived from Bacillus\ua0thuringiensis, and tolerance to the herbicidal active ingredient glufosinate-ammonium by expression of the PAT protein derived from Streptomyces viridochromogenes. The molecular characterisation data did not identify issues requiring assessment for food/feed safety. None of the compositional, agronomic and phenotypic differences identified between maize\ua04114 and the non-genetically modified (GM) comparator(s) required further assessment. There were no concerns regarding the potential toxicity and allergenicity of the newly expressed proteins Cry1F, Cry34Ab1, Cry35Ab1 and PAT, and no evidence that the genetic modification might significantly change the overall allergenicity of maize 4114. The nutritional value of food/feed derived from maize 4114 is not expected to differ from that derived from non-GM maize varieties and no post-market monitoring of food/feed is considered necessary. In the case of accidental release of viable maize\ua04114 grains into the environment, maize\ua04114 would not raise environmental safety concerns. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of maize\ua04114. The genetically modified organism (GMO) Panel\ua0concludes that maize\ua04114 is as safe as the non-GM comparator(s) and non-GM reference varieties with respect to potential effects on human and animal health and the environment in the context of the scope of this application

Novel Decapeptides that Bind Avidly and Deliver Radioisotope to Colon Cancer Cells

The rapidly growing field of targeted tumor therapy often utilizes an antibody, sometimes tagged with a tumor-ablating material such as radioisotope, directed against a specific molecule.This report describes the discovery of nine novel decapeptides which can be radioactively labeled, bind to, and deliver (32)P to colon cancer cells. The decapeptides vary from one another by one to three amino acids and demonstrate vastly different binding abilities. The most avidly binding decapeptide can permanently deliver very high levels of radioisotope to the adenocarcinoma cancer cell lines at an efficiency 35 to 150 times greater than to a variety of other cell types, including cell lines derived from other types of cancer or from normal tissue.This experimental approach represents a new example of a strategy, termed peptide binding therapy, for the potential treatment of colorectal and other adenocarcinomas